Mechanisms of adhesion G protein–coupled receptor activation

Activation of a G proteincoupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans

The innate defenses of the nematode Caenorhabditis elegans have diverged considerably from those of other animals. Perhaps most strikingly, C. elegans has lost the transcription factor NF-κB, key for defense in most animal species, and lacks functional orthologs of many known innate defense receptors1. On the other hand, core signaling pathways involved in innate immunity across a broad range o...

G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G-protein recognition.

G-protein-coupled receptors (GPCRs) play fundamental roles in regulating the activity of virtually every body cell. Upon binding of extracellular ligands, GPCRs interact with a specific subset of heterotrimeric G-proteins that can then, in their activated forms, inhibit or activate various effector enzymes and/or ion channels. Molecular cloning studies have shown that GPCRs form one of the larg...

A direct and functional interaction between the trimeric G protein Go and Rab5 in G proteincoupled receptor signaling

Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation.

The adhesion G protein-coupled receptors (GPCRs) are a distinct family of more than 30 receptors in vertebrate genomes. These receptors have been shown to play pivotal roles in a diverse range of biological functions and are characterized by extremely large N termini featuring various adhesion domains capable of mediating cell-cell and cell-matrix interactions. The adhesion GPCR N termini also ...

Mini Review Adhesion G Protein-Coupled Receptors: Signaling, Pharmacology & Mechanisms of Activation

Word Count: 240 Abstract The adhesion G protein-coupled receptors (GPCRs) are a distinct family of more than 30 receptors in vertebrate genomes. These receptors have been shown to play pivotal roles in a diverse range of biological functions and are characterized by extremely large N-termini featuring various adhesion domains capable of mediating cell-cell and cell-matrix interactions. The adhe...